Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions, is a competitive antagonist of estrogen receptor action in the vasculature.

  • 在此我们发现27-羟基胆甾醇(27HC)是一种含量丰富的胆固醇代谢产物,它的过量引起高胆固醇血症并存于粥样硬化病变中,在血管中是雌激素受体竞争性拮抗剂。
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