Here, it is proposed that a combination of multiple factors may modify selected proteins in vivo, and lead to their misfolding and aggregation in certain cell types.

• 提出如下设想：细胞内的蛋白质分子可能发生多种异常修饰，引起蛋白质选择性错误折叠和聚积而导致神经退行性疾病。