Herein we report on a case of alobar holoprosencephaly diagnosed in the second trimester using both ultrasound (US) and magnetic resonance imaging (MRI).

• 我们在此报告产前以传统超音波及核磁共振造影诊断胎儿空脑症，同时讨论核磁共振造影在产前诊断胎儿空脑症的优点。