How to eliminate the antigenicity of bone xenograft while retaining its osteoinductive activities is an unsolved problem in the orthopaedic field worldwide.

• 异种骨移植是目前世界上骨科领域内尚未解决的难题，其主要困难在于如何消除植骨引起的免疫排斥反应同时保留它的诱导成骨能力。