However, Some of them also have adverse reaction, especially cardiotoxicity, which is related to antihistamines drugs interaction, pharmacokinetics and drug molecular structure.

• 但第2代抗组胺药仍有一些不良反应,尤以心脏的毒性作用,这与抗组胺药物相互作用、药动学、以及药物的分子结构有关。