However, freeze-drying process can induce serious and irreversible damage to liposome, including size increasing, membrane rupture, liposome infusion, membrane infolding, and the drug leakage etc.

• 然而，冷冻干燥技术可以引起严重的和不可逆的损伤，包括粒径的增加、膜的破裂、脂质体的渗漏、膜的折叠和药物的渗漏等等。