However, the concrete mechanism and relationship between the Ca2+ signal transduction and remodeling genes express have not been clarified clearly.

• 我们在以往的2个NSFC中证实了心肌细胞核上存在Ca2+调节系统,证明了不同因素导致的心肌重塑涉及到核Ca2+调节系统,但心肌重塑中Ca2+稳态失衡和Ca2+信号通路与重塑相关基因表达的关系尚未完全阐明。