However, the main mechanism of the bacterial resistance to macrolides is the modification of the target, the methylation of N~6 on A2058 by peptidyl transferase coded by gene erm, which makes the target not to bind to macrolides.

• 而细菌对大环内酯的主要耐药机制是靶点修饰：耐药基因erm编码的甲基转移酶对A2058上的N~6进行甲基化，使这一靶点不能与大环内酯抗生素结合，从而赋予细菌耐药性。