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Keywords Sepsis;Immun tolerance;Immunotherapy; 脓毒症;免疫耐受;免疫疗法;
Induction and maintenance of specific immune tolerance is the Holy Grail of organ transplantation. 诱导宿主产生对移植器官的特异性免疫耐受是人们长期追求的目标。
Islet cell transplantation now forms the basis of a prospective multicenter trial under the aegis of the Immune Tolerance Network. 在免疫耐受网络系统的支持下，现在已经开展胰岛移植前瞻性多中心试验研究。
Objective:To study the mechanism of immune tolerance induce by protal venous injection of donor spleen cells on the dog model of renal transplantation. 目的:利用家犬肾脏移植模型,探讨门静脉注射供体脾细胞诱导免疫耐受的机制。
Once this immune tolerance break down the immune system would attack its own tissue, resulting in autoimmune diseases. 这种免疫耐受一旦破裂，免疫系统就会攻击自身的组织细胞，导致自体免疫疾病。
One aspect we called of them the virologic factors that lead to immune tolerance in vivo. 一部分我们称之为体内导致免疫耐受发生的病毒因素。
With progress of immu nology, the mechanism of immune tolerance is understood better. 随着免疫学的发展,人们对免疫耐受产生机制有了较多的认识。
Over or under-production of BAFF may disturb immune tolerance, thus triggering certain autoimmune disorders. 其缺陷和过度表达均能引起机体免疫失衡，从而诱发多种自身免疫性疾病。
One aspect we call, called of them the virologic factors that lead to immune tolerance in vivo. 一部分我们称之为体内导致免疫耐受发生的病毒因素。
Conclusion: ZPP may induce immune tolerance in BALB / C mouse and the transplanted human lung cancer may be survival in the mouse. 结论： ZPP可引起小鼠对人体肺肿瘤细胞免疫耐受，使移植瘤成活。
Over expression of indoleamine 2,3-dioxygenase(IDO)is an important mechanism that is responsible for immune tolerance of tumor. 吲哚胺2,3-二加氧酶(idoleamine2,3-dioxy-genase,IDO)的高表达是导致肿瘤免疫耐受的一个重要机制。诱导IDO的表达具有两种信号传导途径。
Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting. 造血嵌合能够对肾移植产生持久有力的免疫耐受，但对于皮肤移植无效。
Antigen specific immune tolerance is induced in a mammalian host by administration of a toleragen in combination with a regimen of immunosuppression. 通过施用耐受原与免疫抑制方案相组合诱导哺乳动物宿主中的抗原特异性免疫耐受。
Implantation is of importance during the process of pregnancy.It is very necessary to build mother-fetal immune tolerance for successful pregnancy. 着床是妊娠中的一个重要的过程,成功的着床需要母胎之间免疫耐受的建立。
Conclusion The intrathymic injection of allohepatic cells could not induce immune tolerance of the recipient to the same donor small intestinal graft. 结论胸腺内注入同种异体肝细胞不能诱导受者对同一供者小肠移植物的免疫耐受。
The mechanism of oral administration of insulin inducing immune tolerance in NOD mice[J].Chin J Endocrinol Metab,2002,18(1):67-68. NOD小鼠口服胰岛素诱导免疫耐受机制探讨[J].;中华内分泌代谢杂志;2002;18(1):67-68
Hepatology Digest: Studies have shown that the expression of HBsAg and HBeAg contribute to the immune tolerance of the Hepatitis B virus. 国际肝病：研究表明，HBsAg和HBeAg的表达有助于免疫耐受的发生。
The treatment with IL-12 p35 silenced DCs with anti-CD40L mAb can induce immune tolerance and prolong intestinal allografts survival after transplantation. 术前输注供体来源的IL-12 p35 silenced DC联合CD40L mAb,可在一定程度上抑制小肠移植的排斥反应,诱导受体产生免疫耐受。
Conclusion The thymus may be an immunoprivileged site for islet transplantation and may play an important role during the induction of immune tolerance. 结论胸腺可能为胰岛移植的理想部位，而且在诱导免疫耐受中具有重要作用。
The relationship between the interaction of DCs and its chemokines and the immune tolerance was further understood.A new method for inducing graft immune tolerance may be fund. 随着对DC及其趋化因子间相互作用与免疫耐受关系的进一步认识,最大限度的发挥其耐受潜能,从而探寻诱导移植免疫耐受新的治疗方法。