In addition, by using the HAT domain-deleted p300 mutant, weshowed that the histone acetyltransferase activity of p300/CBP was important in regulation ofWT1 gene expression.

• 此外,通过采用HAT区缺失突变的p300表达质粒的转染实验,我们证明了p300/CBP的组蛋白乙酰转移酶活性在WT1基因转录调控过程中发挥重要作用。