In clinical practice,the interval and dosage of administration are frequently changed,to estimate the plasma concentration of drugs by the method of superposition has practical significance.

• 在临床用药的实际过程中,给药间隔经常是变化的,剂量也会根据临床经验加以调整,在这种情况下,叠加法估算血药浓度就具有实际应用意义。