In conclusion, LIM domain 2 at the C-terminus of hhLIM plays a central role in F-actin polymerization and cytoskeleton stabilization, whereas the first LIM domain is essential for the nuclear localization of hhLIM.

• 结果表明；LIM结构域2在hhLIM与actin相互作用及调节actin细胞骨架组构中起决定性作用.