In present study, the biologic function of anti-CD28 monoclonal antibody and its Fab fragment were investigated in vitro and in vivo.

• 在课题的第一部分，我们通过双向混合淋巴细胞培养实验发现，mAbCD28及其Fab片段可以有效地抑制混合淋巴细胞反应，其作用与剂量成正比。