Indeed, a transient hypercoagulable state may occur when warfarin is initiated without heparin and may lead to abnormal clotting and skin necrosis.

• 的确，初始抗凝治疗单独使用华法令而不合用肝素可以引起短暂的高凝状态，甚至引起异常的凝血状态和皮肤坏死。