Influences of ERK1/2 upstream kinase inhibitor U0126 as well as endothelium integrity on 15-HETE-induced HPV were observed.

• 用ERK1/2上游激酶抑制剂U0126孵育肺动脉环，比较U0126孵育前后15-HETE对缺氧性肺动脉环的收缩作用；