Ischemia cause ET to increase and act upon ETB receptor and induce astrocyte activiation.The active astrocyte can release glutanic acid and promote neuron cells degenerating.

• 缺血导致ET增加并作用于ETB受体，诱导星形胶质细胞激活，星形胶质细胞在激活状态下可释放谷氨酸，促进神经元溃变。