It is central in the chest radiates through to the back or neck and is unaffected by position unless dissection into the pericardium with hemopericardium has produced an acute pericarditis.

• 不过，疼痛是否与二尖瓣脱垂相关，抑或只是一种偶发现象，对此人们尚有争议，因为这种疼痛即便是在无明显脱垂时也很常见。在无重基础性心脏病的特发性房性心动过速者中也常见不明显非典型性胸痛。