It regulates ERK/MAPK pathway and AKT pathway via regulation by p53. ENC-1 can interact with nonphosphorylated p110Rb protein and play roles in neuron cell cycle and differentiation. ENC-1 also has roles in adipocyte differentiation and colon carcinoma.

• ENC-1可以与非磷酸化的p110Rb蛋白相互作用而影响神经元的细胞周期和分化,在脂肪细胞分化和结肠癌发生中ENC-1也起了重要的作用。