J201 shows protective effects on the pulmonary fibrosis induced by bleomycin in rats. Antioxidation and inhibition of the expression of Fas, FasL, MMP-9 and TIMP-2 in lung tissues may be one of the underlying mechanisms.

• J201对实验性大鼠肺纤维化有一定的保护作用,抗氧化作用及抑制Fas、FasL、MMP-9、TIMP-2的表达是其可能的机制之一。