Keratosis of palms and soles is a rare inherited disease transimitted as an autosomal dominant trait.It develops soon after birth and usually reaches the maximum severity by the age of 6 months.

• 摘要手足掌部表皮角质增生症为一遗传性体染色体显性遗传疾病，其主要病微为对称性手足掌部表皮角层增生。