Keywords bone tissue engineering;bone marrow stromal cells;nano-hydroxyapatite/collagen/PLA material;ectopic bone formation;critical calvarial defect;segmental bone defect;

• 骨组织工程;骨髓基质细胞;纳米羟基磷灰石复合胶原/聚乳酸材料;异位成骨;颅骨极限缺损;节段性骨缺损;