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- Expression of mdr 1 gene and multidrug resistance of lung cancer mdrl基因表达与肺癌多重抗药性关系的研究
- Correlation between expression of mdr 1 gene and oncogenes in 人早幼粒白血病HL60细胞及其亚系中mdr-1基因和癌基因表达的关系
- INDUCTION OF EXPRESSION OF MDR 1 GENE BY RETINOIC ACID AND DMSO AND EFFECTS ON RHODAMINE-123 EFFLUX IN HL-60 CELL LINES AND RESISTANT SUBLINES 维甲酸与二甲基亚砜诱导HL-60细胞及其抗性亚型MDR 1的表达和对Rhodamine-123外排的影响
- mdr 1 gene 多药耐药基因
- Method:By using reverse transcriptase polymerase chain reaction (RT PCR), S, mdr 1 and LRP gene expression were studied in 46 de novo AML cases. 方法 :应用RT PCR法检测 4 6例初治AML患者的S、mdr 1和LRPmRNA表达的阳性率。
- High sense mutation of HVR 1 gene was found. (4)HVR1基因有义突变率相当高。
- Mutations in the ABCA 1 gene cause Tangier disease. ABCA 1基因的突变引起Tangier病 (TD)。
- Over expression of PAI 1 gene leads to mesangial ECM accumulation. 首次建立了系膜细胞PAI 1的过度表达体系 ,证实细胞过度表达PAI 1可以直接导致ECM的积聚。
- Expression of mdr 1 was nagative in ATRA resistant HL60 cells. It was negative in resistant APL cells even after ATRA treatment. 结果 对全反式维甲酸 (ATRA)耐药的HL6 0细胞MDR1阴性 ,初发时MDR1为阴性的APL患者复发后仍为阴性。
- The carnosinase 1 gene produces an enzyme called carnosinase. 肌肽酶1基因翻译表达肌肽酶。
- METHODS The reverse transcription polymerase chain reaction(RT PCR) was used to detect expression of mdr 1 mRNA in 20 RCC and 5 normal kidneys. 方法应用逆转录?聚合酶链反应(RT?PCR)技术检测20例肾癌和5例正常肾组织mdr?1基因mRNA的表达。
- Methods Using reverse transcription polymerase chain reaction (RT PCR) technique, we determined the levels of mdr 1 mRNA in 82 breast cancer samples. 方法采用逆转录-多聚酶链式反应技术,检测了82例次乳癌组织的mdr-1mRNA水平。
- There was significant difference in the concentration of DNR between MDR 1 positive and MDR 1 negative cases before and after incubation. MDR1阳性者骨髓细胞内柔红霉素浓度与阴性者相差显著。
- The ratio of CR and the time of disease free surival (DFS) with the MDR 1 +/CD 34 + phenotgpe was significantly less than those of the MDR 1 -/CD 34 - phenotype. MDR1 + / CD34+表型细胞较 MDR1 - / CD34-表型细胞缓解率、生存期、缓解期显著缩短。
- GCH 1 gene mutation is only one of reasons to the DRD patients onset. GCH-1基因突变只是部分DRD患者的发病原因。
- Reverse transcription polymerase chain reaction (RT PCR) assay was used to detect the expression of MDR 1 mRNA and MRP mRNA in 35 patients. Meantime, Immunohistochemistry SABC technique was used to detect P glycoprotein(P gp) in 61 cases. 应用逆转录-多聚酶链式反应(RT-PCR)技术,检测了35 例喉癌患者MDR-1 m RNA、MRPm RNA 基因的表达,同时,应用免疫组化SABC法检测了61 例患者MDR-1 基因产物P-gp。
- Study on expression of IRF?1 gene in human leukemia with RT?PCR and the silver sequence techniques. 逆转录-聚合酶链反应银染分析IRF-1基因在白血病中的表达
- Results 1. The emm 1 gene and emm 3 gene were amplified and identified by blast to CDC data bank. 结果从40381137(T1)和31281187(T3)A组链球菌株的基因组成功克隆emm基因,经测序及blast后分别确认为emm1型和emm3型;
- Genetic heterogeneity existed among clinical isolates,and the major class of the flp 1 gene was class 2. Aa临床分离菌株flp 1基因具有遗传多样性 ,基因型主要为 2型
- Type III collagen is one main type of IMC, which is encoded by Col3a1(collagen type III alpha 1 gene). III型胶原是IMC的主要类型之一,其编码基因为Col3a1(Collagen type III alpha 1 gene)。