MEKK2 also synergized with anti-CD3 antibody to activate JNK in T cells, and stimulation of T cells led to induction of MEKK2 tyrosine phosphorylation.
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美
- MEKK2也是JNK的强烈激活物,能激活JNK依赖的AP-1和IL-2报告基因表达。 当用抗CD28抗体刺激时MEKK2介导的JNK活性无变化,而随着抗CD3抗体刺激,MEKK2介导的JNK活性显著增加。