METHODS A series of pyrrolidine derivatives were synthesized from L-hydroxyproline,and the neuraminidase inhibitory activities of these compounds were tested using high throughput screening.

• 方法以L-羟脯氨酸为原料,合成一系列神经氨酸酶抑制剂,并用高通量活性筛选方法检测其对神经氨酸酶的抑制活性。