METHODS:Artificial gastric juice was used as the dissolution medium ,the tinidazole was determined by UV and the dissolution rate in vitro of four tinidazole solid preparations was estimated.

• 方法:选用人工胃液为溶出介质,以紫外分光光度法测定替硝唑的含量和各制剂的体外溶出度,用单指数模型法,威布尔分布模型法,以及希古契方程拟合。