Methods Clodronate was synthesized by steps of methylenenation,Chloration, acid hydrolysis and salitying from dibromomethane and triethylphosphite.

• 方法以二溴甲烷和亚膦酸三乙酯为原料,经亚甲基化、氯化、酸水解和成盐反应得到氯膦酸二钠。