Methods High, moderate and low dose of adenine and ethambutol were used to Wistar rats.Concentration of serum uric acid and urine nitrogen and creatinine was measured before and after treatment.

• 方法采用腺嘌呤加乙胺丁醇给高、中、低3个剂量组灌胃,测定实验前后大鼠血清尿酸、尿素氮、肌酐,行肾组织病理与超微病理观察。