Methods Ion-exchange resin-drug metformin hydrochloride complexes were prepared as core materials, and followed by coating using ethylcellulose (EC) by the emulsion solvent diffusion technique.

• 方法以自制的离子交换树脂-药物复合物作为核心材料,乙基纤维素(EC)做为包衣材料,用乳化溶剂扩散法制备了盐酸二甲双胍的缓释微囊。