Methods: 3 220 compounds were designed fro m the binding mode of styrylquinoline derivatives in integrase active site using a de novo drug design method, and evaluated by docking simulation.

• 方法:采用从头药物设计方法,从苯乙烯基喹啉抑制剂与整合酶的活性位点出发,产生3220个化合物。