Methods: Immunohistochemical staining by SP method was used to detect the expression of PTEN and FHIT in 62 cases of OSCC, and 12 cases of normal oral membrane.

• 结果：在正常口腔黏膜中PTEN均为强阳性表达(12/12)，在口腔鳞癌中24.；2%25(15/62)表现为PTEN蛋白表达的缺乏或减少；