Methods: Models of chronic epilepsy induced by pentylenetetrazol were established and interactted by TPM, as well as the changes of behavior and EEG at different time-points were observed in rats.

• 方法:采用戊四氮(PTZ)制备大鼠慢性癫痫模型,利用妥泰加以干扰,选取不同的时间点,观察癫痫大鼠行为学及脑电的变化。