Methods: The ED 50, ED 95, ED 99 of cetirizine on histamine induced shock and its LD 50, LD 5, LD 1 were determined by Bliss method. The TI, SF, CSF and SM were calculated.

• 方法 :按Bliss法测定西替利嗪对组胺致豚鼠休克的ED50 、ED95、ED99和对小鼠的LD50 、LD5、LD1,并计算该药的治疗指数、安全系数、可靠安全系数和安全范围。