Methods: The TOB concentration in serum was determined by microbiological method after a single injection dose of TOB or TOB+CEZ.

• 方法:采用微生物法测定8名志愿者单剂量静脉滴注妥布霉素及妥布霉素加头孢唑啉后不同时间血清中妥布霉素的药物浓度。