Methods:Starting from 4-hydroxyphenylacetic acid and pthalide, olopatadine hydrochloride was synthesized via nine synthetic route, such as nucleophilic,substitution, cyclization and Wittig reaction.

• 方法:以对羟基苯乙酸和苯酞为原料,经取代、环合、维蒂希反应等9步反应合成目标产物。