Methods:after musculal injection of progesterone at high and low dosage for one month in female mice,tyrosine and MDA in skin and liver were measured,and skin melanocyte was observed.

• 方法:用黄体酮注射液(高、低两个剂量组)攻击雌性小鼠1个月,以皮肤、肝脏组织酪氨酸、MDA含量变化及皮肤黑色素细胞病理形态学指标作为考察模型是否成功的依据。