Methotrexate is used to treat leukemia and lymphoma; it has been associated with osteoporosis and lung damage. Intrathecal and intravenous methotrexate can cause cognitive impairment.

• 甲氨喋呤用于治疗白血病和淋巴瘤，可引起骨质疏松症和肺损伤。鞘内注射和静脉注射可导致认知损伤。