More than 85%of all cancers express telomeras e activity.Human telome rase has been proposed as a novel and potentially highly selective target for ca ncer therapy.

• 端粒酶与恶性肿瘤的发生、发展关系密切，是肿瘤治疗的一个新的靶点，细胞分化诱导剂抑制端粒酶活性的研究进展明显。