Moreover, non-cytotoxic agents such as small molecules targeting receptor tyrosine kinases and intracellular signaling pathways have been used in the clinical field.

• 替莫唑胺及亚硝基脲类药物耐药性得到了部分解决以及非细胞毒性药物如酪氨酸激酶抑制剂及细胞间信号传导通路抑制剂在临床中的应用。