MyD88 is a critical component in the signaling cascade through Toll-like receptors, interleukin-1 and interleukin-18 receptors.

• 目前已知，MyD88蛋白是 Toll样受体、白介素-1受体、白介素-18受体介导的信号通路中的关键分子，由它参与构成的信号级联最终引起核因子kappa B（Nuclear factor-kappa B，NF-kB）依赖性信号通路的活化。