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- Objective: To assess the change of proadrenomedullin N terminal 20 peptide (PAMP) in patients with essential hypertension. 目的：观察原发性高血压（EH）与肾实质性高血压（RH）患者肾上腺髓质素前体N端20肽（PAMP）的水平变化，探讨PAMP的降压机制。
- N terminal sequence of both 20 and 5KDa are Met, Pro, Leu, Pro, Pro, His, Pro, Gly, His, Pro. 20KDa、5KDa釉基质蛋白N末端前10个氨基酸残基均为：Met、Pro、Leu、Pro、Pro、His、Pro、Gly、His、Pro。
- Objective To obtain the recombinant Eotaxin N Terminal Mutant (Met/Eotaxin) advenvirus, and to study its role in allergic diseases. 目的获取人嗜酸粒细胞亲合素(Eotaxin)N端突变体(Met/Eotaxin)重组腺病毒,探讨其在小鼠变应性鼻炎中的作用。
- Objective: To obtain the antibody against N terminal of 1A6/DRIM, and thereafter get the profile of 1A6/DRIM expression in different cell lines. 目的 :获得 1A6 /DRIM的N端特异性抗体并对其在细胞内的定位进行分析。
- Objective:To investigate of proadrenomedullin N terminal 20 peptide(PAMP)levels in the plasma of the patients with coronary heart disease(CHD). 目的:观察不同类型冠心病与肾上腺髓质素前体N端20肽(Proadrenomedullin N Terminal 20 Peptide,PAMP)的关系。
- The first ten of N terminal amino acid sequence of 12 000 protein in GCF was Met, Leu, Thr, Glu, Leu, Glu, Lys, Ala, Leu, Asn. 龈沟液中低相对分子质量的 12 0 0 0蛋白N 末端 10个氨基酸的顺序为 :Met、Leu、Thr、Glu、Leu、Glu、Lys、Ala、Leu、Asn。
- Conclusions This result indicate that PCR primer introduced V region N terminal changes may seriously affect the antigen binding activity. 结论在构建小分子抗体时，PCR引物引入的氨基酸残基的改变可影响所表达抗体的活性。
- RT PCR showed that all samples expressed HCP gene, only one missense mutation at codon 225 (AAC to AGC, Asn to Ser) within N terminal SH2 domain was found in an ALL patient. RT PCR显示所有标本中都有HCP基因表达 ,仅在 1例急性淋巴细胞性白血病细胞中发现一错义突变 ,发生在HCP基因氨基末端的SH2结构域 ;
- Objective:To explore the relationship between proadrenomedullin N terminal 20 peptide (PAMP) and left ventricular hypertrophy with essential hypertension(EH). 目的:探讨原发性高血压(EH)患者血浆中肾上腺髓质素前体N端20肽(PAMP)与左室肥厚的相互关系。
- Their family proteins contain a conserved NAC domain about 150 amino acids in N terminal ends and highly different transcription regulatory domain in C terminal ends. 其家族成员N端含有保守NAC结构域（约150个氨基酸），C端为高度变异的转录激活区。
- The amino acid sequence in all of these 6 clones is the same,HYEFWAWNWEAN, which is hydrophobic as N terminal of C34.Conclusion This phage display peptide can mimic the epitope of HIV 1 gp41 CHR ,and bind with HIV 1 gp41 NHR. 上述 6个阳性克隆经DNA测序 ,氨基酸序列相同 :HYEFWAWNWEAN ,其明显的疏水性质类似于C34N末端 ,特异性鉴定显示这些克隆均能够与HIV 1gp4 1N多肽结合。 结论 该噬菌体克隆展示肽可模拟HIV 1gp4 1CHR多肽表位 ,并可与N多肽结合
- Objective By intravenous administration of P A M P, the N terminal 22 41 ofadrenom edulline precursor,and calcitonin gene related peptide ( C G R P) ,their effect on heart rhyth m in ratwasinvestigated . 目的 为探讨肾上腺髓质素（ Adreno medullin ， A M） 前体 N 端22?41 的肽（ Pro A M22?41peptide， P A M P） 对心律的影响。
- Keywords ginsenoside;SHSY5Y cells;apoptosis;c jun NH 2 terminal kinase; 关键词人参皂苷;SHSY5Y细胞;细胞凋亡;丝裂素活化蛋白激酶;
- Objective To elucidate the effect of proadrenomedullin N terminal 20 peptide (PAMP) in cardiovascular system and clinical significance of PAMP plasma concentration in the patients with essential hypertension (EH). 目的 探讨肾上腺髓质素前体N端 2 0肽 (PAMP)的心血管效应以及原发性高血压(EH)患者血浆PAMP的浓度变化。
- Objective: To observe the effect of adrenomedullin (ADM) on the production of nitric oxide (NO) in rat aorta and the effect of Proadrenomedullin N terminal 20 peptide (PAMP) and adrenotensin (ADT) on the ADM induced NO production. 目的 :观察肾上腺髓质素 (ADM)对大鼠主动脉一氧化氮 (NO)生成的作用 ,以及肾上腺髓质素原N端 2 0肽 (PAMP)和肾上腺升压素 (ADT)对ADM这一作用的影响。
- The codons for the 84~(th) and 122~(th) amino acids of hFL were changed to those for E and R, and N terminal codons were changed to the optimal ones for Pichia pastoris to elevate the expression level and to increase the biological activity. hFL第84位和122位氨基酸的密码子分别改造为E和R的密码子，并在N端采用甲醇酵母偏爱密码子，以提高hFL的活性和表达量。
- TK gene was 534bp and encoded 178 amino acids. On the N terminal of TK, ATP motif was found. TK gene was conserved in CPV, the identity of GTPV-TY TK gene compared with TK gene in other CPV strains were more than 96%. 试验中首先用PCR方法克隆了GTPV-TY的TK基因,TK基因ORF大小为534bp,编码178个氨基酸,TK的N端具有ATP结合结构域,与其它毒株的TK基因的核苷酸序列比较显示CPV各毒株TK基因的同源性大于96%25,保守性很高。
- AIM To construct the eucaryotic expression vector of the cDNA sequence encoding bioactive N terminal fragment of human bactericidal / permeability increasing protein (BPI) and to express it in COS 7 cells. 目的 构建人杀菌 /通透性增加蛋白 (BPI) N端活性片段 c DNA序列的真核表达载体并了解其在 COS- 7细胞中的表达 .
- AIM: It is to investigate that apoptosis of MDA-MB-435 cell, a human breast cancer cell line, was induced by recombinant retroviral vector mediated CED-4 gene of cadherin 5 N terminal and its apoptosis mechanism. 目的:研究粘附素5 N 端CED-4(cadherin extracellular domain-4)基因经重组逆转录病毒介导转染人乳腺癌细胞MDA-MB-435 及其诱导MDA-MB-435 细胞凋亡的分子调控机制。
- Methods: Acetic acid was selected to extract the enamel matrix proteins. The N terminal amino acid sequence of enamel matrix proteins were determined with SDS-PAGE electrophoretic and blot membrnce analysis. 方法：选择乙酸提取法获得釉基质蛋白，采用SDS－PAGE电泳和印迹膜测序法分析N末端氨基酸序列。
