NHE 1 plays an improtant role in the regulation of pHi. Inhibition of tumor cell reproduction can be caused and their deaths induced by block of the regulation.

• NHE?1 在肿瘤细胞pH 调节中起着重要作用，阻止这一调节能抑制肿瘤细胞的增殖并诱导其凋亡