Nitrates were used in treatment of coronary heart disease and congestive heart failure clinically, but the use of nitrates wasrestricted when nitrate tolerance occurred.

• 硝酸酯类药物在临床上广泛用于冠心病和充血性心力衰竭的治疗;但硝酸酯耐药的出现,使其临床应用受到一定限制。