Nonenzymatic glycosylation may not directly contribute to increasing PKC activity.Long-term increase of PKC activity may enhance the development and progression of diabetic nephropathy.

• 结论 高血糖慢性刺激可引起肾小球PKC活性增高，非酶促糖基化可能未直接参与PKC活性改变，PKC活性长期增高可促进糖尿病肾病发生与发展。