Now the treatment of qulitified hepatitis B string on well treatment. But nucleoside analog(ue) prone to resistance. How can we give treatment when they appeared resistance?

• 问：慢乙肝的治疗倾向于有效的治疗，但核苷类似物药物易于耐药。当耐药发生时，我们应该采取什么样的措施？