OBJECTIVE To investigate the influence of menstruum on solubility of protoberberinium alkaloids in the couple of Rhizoma Coptidis and Fructus Evodiae.

• 目的对比研究水和盐酸甲醇两种溶媒对黄连吴茱萸药对中小檗碱型生物碱溶出率的影响。