Objective To detect the intracellular cisplatin concentration in both multicellular aggregates and monocellular suspension of ovarian cancer cell line COC1 and its cisplatin-resistant subline COC1/DDP.

• 目的 了解人卵巢癌细胞株COC1及其耐药亚株COC1/DDP以多细胞团簇形式和单细胞形式存在的细胞内顺铂浓度的差异 ,探讨细胞存在形式在COC1/DDP耐药中的作用。