Objective To investigate the COX-2, hMLH1 and hMSH2 of genes promoter methylation and MSI frequency in 43 cases of human gastric carcinoma and normal tissues, and to evaluate the relationship between them and occurrence of gastric carcinoma.

• 目的检测临床手术切除43例胃癌及相应正常组织COX-2、hMLH1和hMSH2微卫星不稳定状态MSI及三种基因启动子甲基化情况,并进一步探讨它们与胃癌发生的关系。