Objective To study the feasibility of using high passage human dermal fibroblasts as seed cells for tendon tissue engineering by testing the chromosome variation and tumorigenicity.

• 目的研究高代次人皮肤成纤维细胞的染色体变异性和致肿瘤性,为验证其作为组织工程肌腱种子细胞的安全性提供相应依据。