Other common features of trisomy 13 include the holoprosencephaly complex with distinct facial features.(31,78) Forty percent of cases with trisomy 18 hae cleft lip with or without cleft palate.

• 60%25的病例中，13三体与唇裂和腭裂或单纯腭裂密切相关，13三体常见的其他特征还包括前脑无裂畸形合并明显的面裂[31，78]。