P21, c erbB 2 protein, PCNA index and Dukes stage were independent predictors of survival. The prognosis of patients with P21 and c erbB 2 protein co expression was worse than in patients without this co expression.

• P21、c－erbB－2蛋白、PCNA增殖指数及Dukes分期可作为估计结直肠癌患者预后的独立指标，P21及c－erbB－2蛋白同时表达是预后更差的指征。